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Advances in drug delivery systems, including liposomes and nanophytosomes, address low solubility, rapid metabolism, and limited blood brain barrier penetration, thereby improving central nervous system exposure and pharmacodynamic effects, which is essential for clinical translation of several phytochemicals (Moghaddam et al., 2023

Patients should start with a low dose and increase gradually under medical supervision to minimize side effects

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The resultant reduction in subcutaneous fat can lead to thinner, more vulnerable skin, irrespective of which specific GLP-1 or dual agonist is used

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